Microfluidic system for capture and release of listeria monocytogenes using functionalized core-shell magnetic nanoparticles

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TypeArticle
Proceedings title18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, October 26-30 2014, San Antonio, Texas, USA
ISBN978-1-63439-697-4
Volume1
Pages25462547
SubjectMagnetic capture; Bacteria; Polymer microfluidic device; Array of pillars
AbstractAn integrated polymer-based microfluidic device for capture and release of bacteria using antibodyspecific silica-shell-iron-oxide-core nanoparticles is presented. The magnetic capture-release chip (MCR) relies on a dense array of Nickel-coated high-aspect ratio pillars and a microfluidic channel network for sample delivery, capture, wash and recovery. The unique characteristic of the MCR lies in the ability to control the magnetic field distribution within the chamber without consequent remanence, thus allowing sample capture and release. The capture efficiency was validated using plate-culture method and the minimum detectable concentration for short 15 min bacteria-nanoparticle incubation corresponded to 10 cfu/ml for Listeria monocytogenes.
Publication date
PublisherChemical and Biological Microsystems Society
LanguageEnglish
AffiliationNational Research Council Canada; Medical Devices
Peer reviewedYes
NPARC number23000167
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Record identifier4d55f229-1b09-405c-b9b3-b5561539e088
Record created2016-06-16
Record modified2016-06-16
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