The p75 neurotrophin receptor is localized to primary cilia in adult murine hippocampal dentate gyrus granule cells

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DOIResolve DOI: http://doi.org/10.1016/j.bbrc.2010.09.081
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TypeArticle
Journal titleBiochemical and Biophysical Research Communications
Volume401
Issue3
Pages458462; # of pages: 5
SubjectDentate gyrus; Granule cell; Hippocampus; Primary cilium; p75NTR; TrkA receptor; Alzheimer disease transgenic mice
AbstractThe densely ciliated granule cell layer of the adult murine hippocampal dentate gyrus is one of two sites of adult neurogenesis. The granule cells have already been proven to localize their SSTR3 (somatostatin receptor 3) receptors to their so-called primary cilia. Here we show for the first time that 70�90% of these cells in 7�18 months-old wild-type and 3xTg-AD (Alzheimer disease transgenic) mice also load p75NTR receptors into the structures containing SSTR3, i.e., their primary cilia. On the other hand, p75NTR�s TrkA co-receptors were not localized to cilia but conventionally distributed throughout the cell surface. Significantly fewer cells (20�40%) in the hippocampal CA1 and CA3 regions and cerebral cortex have p75NTR containing cilia. While we don�t know what the impact of the cilial localization of p75NTR on dentate gyral adult neurogenesis and memory encoding might be, the cilia�s amyloid β-activatable p75NTR receptors could be damaging or lethal to the hippocampal functioning of amyloid β�accumulating Alzheimer brain.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17480639
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Record identifier4ef2cfcd-8445-4a42-b2b9-e54ee2135a00
Record created2011-03-30
Record modified2016-05-09
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