Core-shell nanoparticles as prodrugs: Possible cytotoxicological and biomedical impacts of batch-to-batch inconsistencies

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DOIResolve DOI: http://doi.org/10.1016/j.jcis.2012.08.065
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TypeArticle
Journal titleJournal of Colloid and Interface Science
ISSN0021-9797
Volume389
Issue1
Pages292297; # of pages: 6
SubjectAmine oxidation; Batch-to-batch chemical inconsistency; Bond scissions; Chemical variations; Core-shell nanoparticles; Drug carrier; Prodrugs; Side reactions; Targeted drug delivery; Cytotoxicity; Drug delivery; Magnetite; Nanoparticles; Silica; Surface chemistry; Surface reactions; Magnetite nanoparticles; drug carrier; magnetite nanoparticle; reagent; silane; silicon dioxide; article; catalyst; chemical analysis; chemical reaction; chemical structure; cytotoxicity; medical research; oxidation; priority journal; surface property; Drug Carriers; Ferumoxytol; Humans; Nanoparticles; Oxidation-Reduction; Prodrugs; Silanes; Silicon Dioxide; Surface Properties
AbstractNumerous samples of magnetite@silica and magnetite@silica@silane core-shell nanoparticles, previously used as prodrugs, were prepared by an experienced chemist, using the same identical equipment and the same lots of reagents. Their surface analyses showed batch-to-batch chemical variations: no two batches were found to have the same surface chemistries, showing unexpected Si-O bond scission and amine oxidation. Because the preparations used reactions recognized to be mild, and bond scission and oxidation were never previously reported for similar reactions on larger surfaces, the Fe3O4 nanoparticles that form the nanoparticle core appear to have acted as catalysts for these side reactions. The intended use of these nanoparticles, as drug carriers, is discussed in terms of cytotoxicological and biomedical consequences. © 2012 Elsevier Inc.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Industrial Materials Institute (IMI-IMI)
Peer reviewedYes
NPARC number21269764
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Record identifier4f42a3e6-1f47-4888-bed1-69d5a38c9584
Record created2013-12-13
Record modified2016-05-09
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