Surface modification of thermoplastics - towards the plastic biochip for high yhroughput screening devices

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DOIResolve DOI: http://doi.org/10.1039/b700322f
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TypeArticle
Journal titleLab on a Chip
Volume7
Issue7
Pages856862; # of pages: 7
AbstractMicroarrays have become one of the most convenient tools for high throughput screening, supporting major advances in genomics and proteomics. Other important applications can be found in medical diagnostics, detection of biothreats, drug discovery, etc. Integration of microarrays with microfluidic devices can be highly advantageous in terms of portability, shorter analysis time and lower consumption of expensive biological analytes. since fabrication of microfluidic devices using traditional materials such as glass is rather expensive, there is great interest in employing polymeric materials as a low cost alternative that is suitable for mass production. A number of commercially available plastic materials were reviewed for this purpose and poly(methylmethacrylate) Zeonor 1060R and Zeonex E48R were identified as promising candidates, for which methods for surface modification and covalent immobilization of DNA oligonucleotides were developed. In addition, we present proof-of-concept plastic-based microarrays with and without integration with microfluidics.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Industrial Materials Institute; NRC Biotechnology Research Institute
Peer reviewedYes
NRC number53786
NPARC number3539033
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Record identifier4f83b045-d96e-42c2-84b6-c75f6d879217
Record created2009-03-01
Record modified2016-05-09
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