TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins

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DOIResolve DOI: http://doi.org/10.1038/ja.2009.77
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TypeArticle
Journal titleThe Journal of Antibiotics
ISSN0021-8820
1881-1469
Volume62
Issue10
Pages565570; # of pages: 6
SubjectAntibacterial; anticancer; bravomicin; Micromonospora echinospora; polycyclic aromatic; TLN-05220; TLN-05223
AbstractThe deposited strain of the hazimicin producer, Micromonospora echinospora ssp. challisensis NRRL 12255 has considerable biosynthetic capabilities as revealed by genome scanning. Among these is a locus containing both type I and type II PKS genes. The presumed products of this locus, TLN-05220 (1) and TLN-05223 (2), bear a core backbone composed of six fused rings starting with a 2-pyridone moiety. The structures were confirmed by conventional spectral analyses including MS, and 1D and 2D NMR experiments. Comparison of both the 1H and 13C NMR data of the newly isolated compound with those of echinosporamicin and bravomicin A led us to propose a revision of the structure of the latter to include a 2-pyridone instead of the pyran originally postulated. Both compounds (1 and 2) possessed strong antibacterial activity against a series of gram-positive pathogens including several strains of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci (VRE), and cytotoxic activities against several human tumor cell lines. The TLN compounds are the first of this group with reported anticancer activity.
Publication date
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada
Peer reviewedYes
NPARC number21274255
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Record identifier5174ef02-49eb-46f4-9ba0-a4a047351b7b
Record created2015-03-06
Record modified2016-05-09
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