Genomic analysis of the host response to hepatitis C virus infection

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DOIResolve DOI: http://doi.org/10.1073/pnas.202608199
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TypeArticle
Proceedings titleProceedings of the National Academy of Sciences of the United States of America
ConferenceProceedings of PNAS : 2002
ISSN0027-8424
Volume99
Issue24
Pages1566915674; # of pages: 6
SubjectAnimals; Antigen Presentation; Fatty Acids; Gene Expression Profiling; Gene Expression Regulation; Genes, Reporter; Hepacivirus; Hepatitis C; Interferons; Lipid Metabolism; Pan troglodytes; Replicon; Transcription, Genetic; Transfection; Viremia; Virus Replication
AbstractWe have examined the progression of hepatitis C virus (HCV) infections by gene expression analysis of liver biopsies in acutely infected chimpanzees that developed persistent infection, transient viral clearance, or sustained clearance. Both common responses and outcome-specific changes in expression were observed. All chimpanzees showed gene expression patterns consistent with an IFN-alpha response that correlated with the magnitude and duration of infection. Transient and sustained viral clearance were uniquely associated with induction of IFN-gamma-induced genes and other genes involved in antigen processing and presentation and the adaptive immune response. During the early stages of infection, host genes involved in lipid metabolism were also differentially regulated. We also show that drugs that affect these biosynthetic pathways can regulate HCV replication in HCV replicon systems. Our results reveal genome-wide transcriptional changes that reflect the establishment, spread, and control of infection, and they reveal potentially unique antiviral programs associated with clearance of HCV infection.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier10062105
NPARC number12327296
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Record identifier519de4e9-3173-4cfc-ba14-26c60cd345cd
Record created2009-09-10
Record modified2016-05-09
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