Magnetic resonance microscopy for assessment of morphological changes in hydrating hydroxypropylmethyl cellulose matrix tablets in situ

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DOIResolve DOI: http://doi.org/10.1007/s11095-012-0837-y
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TypeArticle
Journal titlePharmaceutical Research
ISSN0724-8741
1573-904X
Volume29
Issue12
Pages34203433; # of pages: 14
Subjectcontrolled release; hydroxypropylmethyl cellulose (HPMC); pharmaceutical magnetic resonance imaging (MRI); swellable matrix tablets; T2 magnetic resonance relaxometry
AbstractPurpose To resolve contradictions found in morphology of hydrating hydroxypropylmethyl cellulose (HPMC) matrix as studied using Magnetic Resonance Imaging (MRI) techniques. Until now, two approaches were used in the literature: either two or three regions that differ in physicochemical properties were identified. Methods Multiparametric, spatially and temporally resolved T2 MR relaxometry in situ was applied to study the hydration progress in HPMC matrix tablets using a 11.7 T MRI system. Two spin-echo based pulse sequences—one of them designed to specifically study short T2 signals—were used. Results Two components in the T2 decay envelope were estimated and spatial distributions of their parameters, i.e. amplitudes and T2 values, were obtained. Based on the data, five different regions and their temporal evolution were identified: dry glassy, hydrated solid like, two interface layers and gel layer. The regions were found to be separated by four evolving fronts identified as penetration, full hydration, total gelification and apparent erosion. Conclusions The MRI results showed morphological details of the hydrating HPMC matrices matching compound theoretical models. The proposed method will allow for adequate evaluation of controlled release polymeric matrix systems loaded with drug substances of different solubility.
Publication date
LanguageEnglish
AffiliationAquatic and Crop Resource Development; Medical Devices; National Research Council Canada
Peer reviewedYes
Identifier837
NPARC number21268403
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Record identifier532b8c86-79f5-478f-b689-b3700641f26c
Record created2013-07-10
Record modified2016-05-09
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