Applications of amniotic membrane and fluid in stem cell biology and regenerative medicine

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Journal titleStem Cells International
Article number721538
Subject5' nucleotidase; beta1 integrin; endoglin; epidermal growth factor; fibroblast growth factor; Hermes antigen; octamer transcription factor 4; scatter factor; stage specific embryo antigen 4; Thy 1 antigen; tissue scaffold; transcription factor NANOG; transcription factor Sox2; transforming growth factor; acute kidney tubule necrosis; amnion; amnion fluid; bladder injury; brain injury; brain ischemia; cell differentiation; cell transplantation; diabetes mellitus; diaphragm hernia; heart failure; heart infarction; human; leg ischemia; liver cirrhosis; nonhuman; paracrine signaling; Parkinson disease; priority journal; protein expression; pulmonary hypertension; regenerative medicine; review; sciatic nerve injury; skin defect; skin graft; spinal muscular atrophy; stem cell transplantation; therapy effect; tissue engineering; tissue repair
AbstractThe amniotic membrane (AM) and amniotic fluid (AF) have a long history of use in surgical and prenatal diagnostic applications, respectively. In addition, the discovery of cell populations in AM and AF which are widely accessible, nontumorigenic and capable of differentiating into a variety of cell types has stimulated a flurry of research aimed at characterizing the cells and evaluating their potential utility in regenerative medicine. While a major focus of research has been the use of amniotic membrane and fluid in tissue engineering and cell replacement, AM- and AF-derived cells may also have capabilities in protecting and stimulating the repair of injured tissues via paracrine actions, and acting as vectors for biodelivery of exogenous factors to treat injury and diseases. Much progress has been made since the discovery of AM and AF cells with stem cell characteristics nearly a decade ago, but there remain a number of problematic issues stemming from the inherent heterogeneity of these cells as well as inconsistencies in isolation and culturing methods which must be addressed to advance the field towards the development of cell-based therapies. Here, we provide an overview of the recent progress and future perspectives in the use of AM- and AF-derived cells for therapeutic applications.
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AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
NPARC number21270205
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Record identifier532c042a-fd5e-41b6-85ed-3979c29b98ef
Record created2014-01-10
Record modified2016-05-09
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