Magnetic resonance imaging tracking of alginate beads used for drug delivery of growth factors at sites of cardiac damage.

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DOIResolve DOI: http://doi.org/10.1016/j.mri.2009.01.023
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TypeArticle
Journal titleMagnetic Resonance Imaging
Volume27
Issue7
Pages970975; # of pages: 6
SubjectDrug delivery; Alginate beads; MR contrast agent; Myocardial repair
AbstractAlginate-based beads labeled with contrast agent and loaded with vascular growth hormones were used for site-specific chronic delivery of hormones at the site of myocardial damage in a porcine model. Position of the beads within the pericardium could be monitored by MRI for optimal hormone delivery due to the presence of contrast agent. The beads facilitate the slow release of cytochrome c, myoglobin and methemoglobin used as protein models of growth factors. This application allows for site-specific delivery of hormones while the incorporated contrast agent in the beads provides a tool for MRI tracking in chronic studies.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number20171301
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Record identifier550e7e01-a4dd-45c2-a466-9509c2432867
Record created2012-06-22
Record modified2016-05-09
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