Transcription factor substitution during the evolution of fungal ribosome regulation

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DOIResolve DOI: http://doi.org/10.1016/j.molcel.2008.02.006
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TypeArticle
Journal titleMolecular Cell
Volume29
Issue5
Pages552562; # of pages: 11
AbstractCoordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been well characterized in the yeast Saccharomyces cerevisiae. We have used whole-genome transcriptional and location profiling to establish that, in Candida albicans, the RP regulon is controlled by the Myb domain protein Tbf1 working in conjunction with Cbf1. These two factors bind both the promoters of RP genes and the rDNA locus; Tbf1 activates transcription at these loci and is essential. Orthologs of Tbf1 bind TTAGGG telomeric repeats in most eukaryotes, and TTAGGG cis-elements are present upstream of RP genes in plants and fungi, suggesting that Tbf1 was involved in both functions in ancestral eukaryotes. In all Hemiascomycetes, Rap1 substituted Tbf1 at telomeres and, in the S. cerevisiae lineage, this substitution also occurred independently at RP genes, illustrating the extreme adaptability and flexibility of transcriptional regulatory networks.
Publication date
PublisherElsevier
LanguageEnglish
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedYes
NRC number49542
NPARC number21268263
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Record identifier562a5be2-9621-4a2f-b2f5-1a50c3a8c7ad
Record created2013-06-11
Record modified2016-05-09
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