Galactosyltransferase B3galt2 is required for dendrite outgrowth of the layer V pyramidal neurons in the mouse cerebral cortex

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DOIResolve DOI: http://doi.org/10.1093/glycob/cwq137
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TypeAbstract
Proceedings titleGlycobiology
ConferenceAnnual Meeting of the Society for Glycobiology (SFG 2010), November 7-10, 2010, St. Petersburg, Florida, USA
ISSN0959-6658
1460-2423
Volume20
Issue11
Pages14761476; # of pages: 1
AbstractFactors that regulate neurite outgrowth are important in determining the wiring of the central nervous system. Glycosylation is known to play a role in regulation of neurite outgrowth. However, the underlying mechanisms remain unclear. Here we describe that a UDP-Gal:β GlcNAc β- 1,3-galactosyltransferase (B3GalT2) is strongly expressed in neurons in the layers V and VI of the cerebral cortex and in the hippocampus during postnatal development of the mouse brain. We also show that cortical layer V pyramidal neurons of B3GalT2 gene knockout mice exhibit reduced apical dendrite length, reduced spine numbers, and aberrant apical dendrite direction. Together, our results demonstrate for the first time that B3GalT2 is an important regulator of neuritogenesis.
Publication date
PublisherOxford University Press
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17482878
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Record identifier56b91737-d9ce-4e58-ae55-c64c259e101a
Record created2011-03-30
Record modified2016-08-22
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