Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis

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DOIResolve DOI: http://doi.org/10.1351/pac200577010163
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titlePure and Applied Chemistry
ISSN0033-4545
Volume77
Issue1
Pages163178; # of pages: 16
Subjectantifungal activity; anti-inflammatory activity; aspergillosis; ICAM-1 inhibition; lignans; long-chain esters and amides; medicinal plants; neolignans; piper species
AbstractDue to the growing interest in small molecules that could help in understanding protein-protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has grown significantly. Many of these pathways are highly complex and present tremendous challenges with the use of classical tools. A rapid access to natural product-like small molecules having structural complexity and diversity is crucial for systematically dissecting the functions of complex protein networking and understanding cell signaling pathways. The complex nature, the three-dimensional architecture, and the number of protein binding functional groups presented in three-dimensional arrays are some of the attractive features to incorporate in smallmolecule chemical probes to be used as modulators of protein function.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier10159745
NPARC number12340928
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Record identifier56f4a6cd-9d2d-4ff4-af9f-ee7684cd1285
Record created2009-09-11
Record modified2016-05-09
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