Stereoselective Synthesis of Neo-c-glycopeptide Building Blocks: Towards a Flexible and Control-oriented Design as probes for Carbonhydrate-protein Interactions

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DOIResolve DOI: http://doi.org/10.1016/S0960-894X(97)00255-2
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TypeArticle
Journal titleBioorganic & Medicinal Chemistry Letter
Volume7
Issue12
Pages15371542; # of pages: 6
AbstractNeo-C-glycopeptides (1-4) have been synthesized as building blocks to obtain higher neo-Cglycopeptides as probes for studying carbohydrate-protein interactions. A convergent approach for the synthesis of 4 has been developed, in which two galactose units are attached to a glycine derivative in a stepwise procedure (reductive amination followed by amide coupling) and finally coupling to the protected dipeptide having a free amino group on the side chain.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
NPARC number12327875
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Record identifier571c0ba7-177a-4b21-b1c4-77d151416285
Record created2009-09-10
Record modified2016-05-09
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