The effects of cholesterol and β-sitosterol on the structure of saturated diacylphosphatidylcholine bilayers

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DOIResolve DOI: http://doi.org/10.1007/s00249-010-0635-6
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TypeArticle
Journal titleEuropean Biophysics Journal
Volume40
Issue2
Pages153163; # of pages: 11
SubjectCholesterol; β-Sitosterol; Repeat distance; Bilayer thickness; Undulation
AbstractThe structures of DMPC and DPPC bilayers in unilamellar liposomes, in the presence of 33.3 mol% cholesterol or the plant sterol β-sitosterol, have been studied by small-angle neutron scattering. The bilayer thickness d L increases in a similar way for both sterols. The repeat distance in multilamellar liposomes, as determined by small-angle X-ray diffraction, is larger in the presence of β-sitosterol than in the presence of cholesterol. We observe that each sterol modifies the interlamellar water layer differently, cholesterol reducing its thickness more efficiently than β-sitosterol, and conclude that cholesterol suppresses bilayer undulations more effectively than β-sitosterol.
Publication date
PublisherSpringer
LanguageEnglish
AffiliationNRC Canadian Neutron Beam Centre; National Research Council Canada
Peer reviewedYes
NPARC number17101695
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Record identifier5753ba6e-fa9f-464d-959b-3bf9d3c001a2
Record created2011-03-08
Record modified2016-05-09
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