Morphological modification of nanostructured ultrathin-layer chromatography stationary phases

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Journal titleJournal of Chromatography A
Pages72037210; # of pages: 8
SubjectGlancing angle deposition; High-quality separation; Layer microstructures; Migration velocity; Morphological modification; Nanostructured thin film; Performance benefits; Rapid separation; Reactive ion etching (RIE); Separation performance; Separation zone; Shadow mask; Silica thin films; Stationary phase; Concentration (process); Morphology; Vapor deposition; Reactive ion etching; silicon dioxide; analytic method; chemical modification; chemical reaction kinetics; concentration (parameters); elution; glancing angle deposition; high performance thin layer chromatography; intermethod comparison; nanoanalysis; nanofabrication; performance measurement system; phase transition; reactive ion etching; separation technique; structure analysis; ultrathin layer chromatography; Benzoin; beta-Cyclodextrins; Borates; Microscopy, Electron, Scanning; Stereoisomerism
AbstractUltrathin-layer chromatography (UTLC) provides the high sensitivities and rapid separations over short distances desirable in many analytical applications. The dependence of these performance benefits on UTLC layer microstructure motivates continued stationary phase engineering efforts. A new method of modifying the elution behaviours of nanostructured thin film UTLC stationary phases is investigated in this report. Macroporous normal phase silica thin films ~5μm thick were fabricated using glancing angle deposition (GLAD). Reactive ion etching (RIE) and a subsequent annealing treatment modified stationary phase morphology to tune migration velocity, analyte retention, and overall separation performance. Combining this technique with a RIE shadow mask enabled fabrication of adjacent concentration and separation zones with markedly different elution properties. Although produced using an entirely new approach, GLAD UTLC concentration zone media behaved in a manner consistent with traditional thin-layer chromatography (TLC) and high-performance TLC (HPTLC) concentration zone plates. In particular, these new media focused large volume, low concentration dye mixture spots into narrow bands to achieve high-quality separations. The described approach to modifying the morphology and resultant elution behaviours of nanostructured stationary phases expands the capabilities of the GLAD UTLC technique. © 2011 Elsevier B.V.
Publication date
AffiliationNational Research Council Canada (NRC-CNRC); Security and Disruptive Technologies
Peer reviewedYes
NPARC number21271983
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Record identifier59cc63b5-91a4-4739-bee6-059327bd56ab
Record created2014-05-15
Record modified2016-05-09
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