Hydrophobic triaryl-substituted β-lactams as activity-based probes for profiling eukaryotic enzymes and host-pathogen interactions

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DOIResolve DOI: http://doi.org/10.1002/cbic.201402097
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TypeArticle
Journal titleChemBioChem
ISSN1439-4227
Volume15
Issue15
Pages21952200; # of pages: 6
Subjectbeta lactam derivative; enzyme; eukaryote; fluorescence; gel electrophoresis; host pathogen interaction; hydrophobicity; liquid chromatography; molecular probe; protein analysis; tandem mass spectrometry
AbstractABPP with β-lactams: We identified the eukaryotic targets of β-lactam-containing compounds by activity-based protein profiling. Using this method, we demonstrated that β-lactam-based activity probes can be applied to identify differentially active enzymes in different cell lines and during hepatitis C virus replication.
Publication date
PublisherWiley
LanguageEnglish
AffiliationNational Research Council Canada; Medical Devices; Human Health Therapeutics
Peer reviewedYes
NPARC number21272734
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Record identifier5a84f256-3ea2-4d75-b07f-ba7a461ef57f
Record created2014-12-03
Record modified2016-05-09
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