Self-priming of liquids in capillary autonomous microfluidic systems

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Journal titleMicrofluidics and Nanofluidics
Pages371382; # of pages: 12
Subject3-D microfluidic; Air bubbles; Autonomous systems; Biological fluids; Capillary rise; Complete wetting; Complex 3D geometry; Contact line dynamics; Critical parameter; Geometrical optimization; Lattice Boltzmann method; Liquid gas interface; Liquid solids; Liquid water; Micro fluidic system; Micro-chambers; Micro-fluidic devices; Microfluidic cavity; Microfluidic channel; Numerical approaches; Numerical models; Numerical results; Parallel implementations; Performance criterion; Physical process; Quantitative effects; Rectangular cavity; Self-priming; Target regions; Capillary flow; Contact angle; Dynamics; Fluidic devices; Liquids; Numerical methods; Optimization; Phase interfaces; Three dimensional; Wetting; Microfluidics
AbstractWe present a numerical approach to the capillary rise dynamics in microfluidic channels of complex 3D geometries. In order to optimize the delivery of specific biological fluids to target regions in microfluidic capillary autonomous systems (CAS), we analyze self-priming of liquid water into a microfluidic device consisting of a microfluidic channel that feeds a rectangular microfluidic cavity trough an appropriately designed micro-chamber. The target performance criteria in our optimization are (1) fast and complete wetting of the cavity bottom while (2) minimizing the probability of trapping air bubble in the device. The numerical model is based on the lattice Boltzmann method (LBM) and a three-dimensional single-component multiple-phase (SCMP) scheme. By using a parallel implementation of this algorithm, we investigate the physical processes related to the invasion of the liquid-gas interfaces in rectangular cavities at different liquid-solid contact angle and shapes of the transition micro-chamber. The numerical results has successfully captured important qualitative and some key quantitative effects of the liquid-solid contact angle, the roughness of the cavity edges, the depth of the holes and shape of the micro-chambers. Moreover, we present and validate experimentally simple geometrical optimizations of the microfluidic device that ensure the complete filling the microfluidic cavity with liquid. Critical parameters related to the overall priming time of the device are presented as well. © 2011 Crown Copyright as represented by the National Research Council.
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AffiliationNational Research Council Canada (NRC-CNRC); NRC Industrial Materials Institute (IMI-IMI); NRC Steacie Institute for Molecular Sciences (SIMS-ISSM)
Peer reviewedYes
NPARC number21269301
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Record identifier5bc506ac-d294-43f8-973d-b8c60af3a295
Record created2013-12-12
Record modified2016-05-09
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