Towards radiolabeled G∧C module for cellular imaging of bioactive Rosette nanotubes

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DOIResolve DOI: http://doi.org/10.1557/opl.2011.433
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TypeArticle
Proceedings titleNanofunctional Materials, Nanostructures and Nanodevices for Biomedical Applications II
Series titleMaterials Research Society Symposium Proceedings; Volume 1316
Conference2010 MRS Fall Meeting: Symposium QQ: Nanofunctional Materials, Nanostructures and Nanodevices for Biomedical Applications II, November 29 - December 3, 2010, Boston, MA, USA
ISSN0272-9172
ISBN9781618395207
Pages3034; # of pages: 5
SubjectAqueous condition; Bioactive molecules; Biologically inspired; Cellular imaging; Cellular uptake; Drug delivery vehicles; Functionalized; Guanine cytosines; In-vivo; Inflammatory disorders; Physiological condition; Radiolabeling; Spect (single photon emission computed tomography); Triglycine; Chelation; Diseases; Drug delivery; Medical applications; Nanotubes; Radioisotopes; Self assembly; Rhenium compounds
AbstractRosette nanotubes (RNTs) are obtained through the self-organization of biologically inspired self-complementary guanine-cytosine modules (G∧C motif) under physiological conditions. These architectures can express bioactive molecules on their surface by functionalizing the G∧C motif prior to self-assembly. As a result, RNTs are promising drug delivery vehicles for the treatment of diseases such as cancer and inflammatory disorders. Towards these studies, we have explored the toxicity and immunological response of RNTs and are now focused on understanding their cellular uptake, biological distribution and kinetics in vivo. For these investigations, we need to construct a RNT labeled with a radionuclide that can be followed in vivo by SPECT (single photon emission computed tomography) imaging. In this proceeding, we describe a twin G∧C motif that is functionalized with mercaptoacetyl triglycine (MAG 3). This is a well known ligand which is able to form a stable chelate with the radionuclides 99mTc or 186/188Re. In order to develop the chemistry for this radiolabeling strategy for the RNTs, we demonstrate the chelation of the MAG 3 functionalized twin-G∧C motif with cold rhenium and investigate the self-assembly properties of the complex into RNTs under aqueous conditions. © 2011 Materials Research Society.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); National Institute for Nanotechnology
Peer reviewedYes
NPARC number21271998
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Record identifier5be3b442-1840-4398-b23a-f76b610a2f83
Record created2014-05-16
Record modified2016-05-09
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