Advances in coupling microfluidic chips to mass spectrometry

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DOIResolve DOI: http://doi.org/10.1002/mas.21417
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TypeArticle
Journal titleMass Spectrometry Reviews
ISSN0277-7037
Volume34
Pages535557
AbstractMicrofluidic technology has shown advantages of low sample consumption, reduced analysis time, high throughput, and potential for integration and automation. Coupling microfluidic chips to mass spectrometry (Chip-MS) can greatly improve the overall analytical performance of MS-based approaches and expand their potential applications. In this article, we review the advances of Chip-MS in the past decade, covering innovations in microchip fabrication, microchips coupled to electrospray ionization (ESI)-MS and matrix-assisted laser desorption/ionization (MALDI)-MS. Development of integrated microfluidic systems for automated MS analysis will be further documented, as well as recent applications of Chip-MS in proteomics, metabolomics, cell analysis, and clinical diagnosis.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); Human Health Therapeutics
Peer reviewedYes
NPARC number21270773
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Record identifier5c05312f-dfff-46c7-8532-edec07962bf9
Record created2014-02-17
Record modified2016-08-19
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