Immune-deficient drosophila melanogaster : a model for the innate immune response to human fungal pathogens

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TypeArticle
Journal titleThe Journal of Immunololgy
Volume172
Issue9
Pages56225628; # of pages: 7
AbstractWe explored the host-pathogen interactions of the human opportunistic fungus Candida albicans using Drosophila melanogaster. We established that a Drosophila strain devoid of functional Toll receptor is highly susceptible to the human pathogen C. albicans. Using this sensitive strain, we have been able to show that a set of specific C. albicans mutants of different virulence in mammalian infection models are also impaired in virulence in Drosophila and remarkably display the same rank order of virulence. This immunodeficient insect model also revealed virulence properties undetected in an immunocompetent murine model of infection. The genetic systems available in both host and pathogen will enable the identification of host-specific components and C. albicans genes involved in the host-fungal interplay.
Publication date
Linkhttp://www.jimmunol.org/content/172/9/5622
LanguageEnglish
AffiliationNational Research Council Canada; NRC Biotechnology Research Institute
Peer reviewedNo
NPARC number12328076
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Record identifier5c51efa4-d130-476d-a809-7c2aeec0bf23
Record created2009-09-10
Record modified2016-05-09
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