Lipopolysaccharide structure of Helicobacter pylori serogroup O:3

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DOIResolve DOI: http://doi.org/10.1016/j.carres.2013.03.008
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TypeArticle
Journal titleCarbohydrate Research
ISSN0008-6215
Volume378
Pages139143; # of pages: 5
SubjectGeneral architectures; Helicobacter pylori; Linear assembly; Lipopolysaccharides; LPS; MALDI-MS; MS; O-Chain; Nuclear magnetic resonance; Organic compounds; Structure (composition); Synthesis (chemical); Chains; bacterium lipopolysaccharide; dextran; heptane; oligosaccharide; oxygen; polysaccharide; analytic method; animal cell; article; bacterial strain; biodegradation; carbohydrate analysis; chemical composition; controlled study; Helicobacter pylori; mass spectrometry; matrix assisted laser desorption ionization time of flight mass spectrometry; nonhuman; nuclear magnetic resonance spectroscopy; priority journal; substitution reaction; Helicobacter pylori
AbstractIn this study, we describe a re-investigation of the lipopolysaccharide structure of Helicobacter pylori serogroup O:3. Application of NMR and MS approaches to the analysis of oligosaccharides obtained through degradation of LPS from H. pylori serogroup O:3 by various methods confirmed that its general architecture was identical to that of LPS from H. pylori strains 26695 and SS1 and followed a sequential linear assembly of the α-1,6-glucan, DD-heptan, and O-chain components. Additionally, MALDI-MS analysis demonstrated that a significant proportion of H. pylori serogroup O:3 LPS was terminated with α-1,6-glucan and was not further substituted by DD-heptan and the O-chain polysaccharide. Crown Copyright © 2013 Published by Elsevier Ltd.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21270743
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Record identifier5cad97e7-db88-4c7d-9e14-ce6451c6dc77
Record created2014-02-17
Record modified2016-05-09
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