Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

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DOIResolve DOI: http://doi.org/10.1016/j.jneuroim.2009.12.006
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TypeArticle
Journal titleJournal of Neuroimmunology
Issue220
Pages1724; # of pages: 8
SubjectStress; Mast cells; IgE, Substance P
AbstractThe effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcεRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress.
Publication date
LanguageEnglish
AffiliationNRC Institute for Nutrisciences and Health; National Research Council Canada
Peer reviewedYes
NPARC number17326692
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Record identifier5d663a36-0248-49b1-b8b5-14f065076ea2
Record created2011-03-18
Record modified2016-05-09
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