Immunobiology of African trypanosomes: need of alternative interventions

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DOIResolve DOI: http://doi.org/10.1155/2010/389153
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TypeArticle
Journal titleJournal of Biomedicine and Biotechnology
Volume2010
IssueArticle ID 389153
Pages124; # of pages: 24
AbstractTrypanosomiasis is one of the major parasitic diseases for which control is still far from reality. The vaccination approaches by using dominant surface proteins have not been successful, mainly due to antigenic variation of the parasite surface coat. On the other hand, the chemotherapeutic drugs in current use for the treatment of this disease are toxic and problems of resistance are increasing (see Kennedy (2004) and Legros et al. (2002)). Therefore, alternative approaches in both treatment and vaccination against trypanosomiasis are needed at this time. To be able to design and develop such alternatives, the biology of this parasite and the host response against the pathogen need to be studied. These two aspects of this disease with few examples of alternative approaches are discussed here.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17401044
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Record identifier617e8d7c-a168-4c2e-9838-5187601dd01e
Record created2011-03-25
Record modified2016-05-09
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