Structural aspects of recently discovered viral deubiquitinating activities

DOIResolve DOI: http://doi.org/10.1515/BC.2006.108
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TypeArticle
Volume387
Issue7
Pages853862; # of pages: 10
SubjectBiotechnology; Enzymes; HPC; pha; Protein; Proteins
AbstractProtein ubiquitination has been identified as a regulatory mechanism in key cellular activities, and deubiquitination is recognized as an important step in processes governed by ubiquitin and ubiquitin-like modifiers. Viruses are known to target ubiquitin and ubiquitin-like modifier pathways using various strategies, including the recruitment of host deubiquitinating enzymes. Deubiquitinating activities have recently been described for proteins from three different virus families (adenovirus, coronavirus and herpesvirus), and predicted for others. This review centers on structural-functional aspects that characterize the confirmed viral deubiquitinating enzymes, and their relationships to established families of cellular deubiquitinating enzymes
Publication date
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedNo
NRC number47526
NPARC number3538834
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Record identifier62308830-65ac-4061-81dc-a6a956c9e711
Record created2009-03-01
Record modified2016-05-09
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