Quantitative radio-labeled biomolecule detection using a functionalized CMOS sensor

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DOIResolve DOI: http://doi.org/10.1109/TNS.2014.2311588
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TypeArticle
Journal titleIEEE Transactions on Nuclear Science
ISSN0018-9499
Volume61
Issue3
Article number6819065
Pages11121117; # of pages: 6
SubjectAdenosinetriphosphate; CMOS integrated circuits; Detectors; Fluorescence; Radioactive tracers; Aptamers; Biomolecule detection; CMOS imagers; Geant4; Radiolabel; Biomolecules
AbstractFor the first time, a CMOS imager has been used to detect the presence of radio-labeled target biomolecules captured on a functionalized surface. A CMOS image sensor from an SLR camera was used. Using aptamer functionalization the system successfully detected 32P labeled adenosine triphosphate (ATP) at concentrations well below those typically associated with fluorescence-based sensor architectures. The system has also demonstrated its amenability to multiplexed/spotted biomolecule detection. GEANT4, a Monte Carlo toolkit for simulating the passage of radiation through matter, was used to analyze the detector. Radiolabel detection offers the potential for direct quantitative measurement of bound biomolecules which is advantageous compared to the use of fluorescent tags.
Publication date
PublisherIEEE
LanguageEnglish
AffiliationNational Research Council Canada; Security and Disruptive Technologies; Measurement Science and Standards
Peer reviewedYes
NPARC number21272640
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Record identifier6282f5a5-96c7-4217-a9bd-e86e90701027
Record created2014-12-03
Record modified2016-11-29
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