Computational Sequence Design Techniques for DNA Microarray Technologies

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TypeBook Chapter
Book titleSystematic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances
Pages# of pages: 30
AbstractIn systems biology and biomedical research, microarray technology is a method of choice that enables the complete quantitative and qualitative ascertainment of gene expression patterns for whole genomes. The selection of high quality oligonucleotide sequences that behave consistently across multiple experiments is a key step in the design, fabrication and experimental performance of DNA microarrays. The aim of this chapter is to outline recent algorithmic developments in microarray probe design, evaluate existing probe sequences used in commercial arrays, and suggest methodologies that have the potential to improve on existing design techniques.
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AffiliationNRC Institute for Information Technology; National Research Council Canada
Peer reviewedYes
NPARC number18608248
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Record identifier63fcb134-6145-4d1f-b1bc-a10ac6ac7a19
Record created2011-09-21
Record modified2016-05-09
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