Polysaccharide-peptide complexes from Serratia marcescens cells

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DOIResolve DOI: http://doi.org/10.1139/o64-072
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TypeArticle
Journal titleCanadian Journal of Biochemistry
ISSN0008-4018
Volume42
Issue5
Pages593603; # of pages: 11
AbstractDeterminations were made of the chemical composition and antitumor properties of several polysaccharide fractions obtained by high speed centrifugation of aqueous extracts of the cells of Serratia marcescens following phenol extraction and trypsin digestion. The use of methods that ensured complete removal of lipid gave polysaccharides containing firmly bound amino acid residues. These were highly effective in causing complete regression of well established solid tumors in mice. The products derived primarily from the cell wall were more potent than the polysaccharides of extracellular and cytoplasmic origins. Extensive differences were also noted in the chemical composition of the polysaccharide complexes isolated from the two sources.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada
Peer reviewedYes
NRC number7823
NPARC number21274518
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Record identifier64c0ec05-eb74-4bb5-bb82-060d7959b78e
Record created2015-03-16
Record modified2016-05-09
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