Gas-phase conformers of the [M + 2H]2+ ion of bradykinin investigated by combining high-field asymmetric waveform ion mobility spectrometry, hydrogen/deuterium exchange, and energy-loss measurements

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DOIResolve DOI: http://doi.org/10.1002/rcm.390
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TypeArticle
Journal titleRapid communications in mass spectrometry
ISSN0951-4198
Volume15
IssueAugust 16
Pages14531456; # of pages: 4
AbstractThe continuous separation capability of high-field asymmetric waveform ion mobility spectrometry (FAIMS) was used in combination with complementary techniques for probing biomolecular ions in the gas phase. Gas-phase conformers of the [M + 2H]2+ ion of bradykinin were examined using a combination of FAIMS, H/D exchange, and energy-loss measurements. When FAIMS data and H/D exchange data were analyzed separately, the presence of only two conformers of the [M + 2H]2+ ion of bradykinin could be detected. However, in an experiment in which FAIMS and H/D exchange were combined, at least four different conformers of the gas-phase [M + 2H]2+ ion of bradykinin were detected, including one of very low abundance. Cross sections calculated for the four conformers, based on energy-loss measurements, were 250, 240, 250, and 244 Å2, in order of decreasing abundance.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for National Measurement Standards
Peer reviewedNo
Identifier10422936
NRC number123
NPARC number8897733
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Record identifier6562f603-d3d5-47b4-bf35-f2561e50660f
Record created2009-04-22
Record modified2016-05-09
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