A secreted enzyme reporter system for MRI

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DOIResolve DOI: http://doi.org/10.1002/anie.200906712
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Journal titleAngewandte Chemie - International Edition
Pages39093911; # of pages: 3
Subjectactivity; Alkaline Phosphatase; Aptamers; bio; Biotechnology; Enzymatic reporters; Gene reporters; Magnetic Resonance Imaging; phosphatase
Abstract(Figure Presented) Let's see what comes out: An extracellular enzymatic gene-reporter system for magnetic resonance imaging (MRI) yields strong, reversible contrast changes in response to the expression of secreted alkaline phosphatase (SEAP; see picture). Products of SEAP activity were specifically detected using an iron-oxide-based sensor. The contrast agent is not used up by the enzyme, cell delivery is not required, and multimodal detection is possible.
Publication date
AffiliationNational Research Council Canada (NRC-CNRC); NRC Biotechnology Research Institute
Peer reviewedYes
NRC number52751
NPARC number16225342
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Record identifier657d334c-302f-4012-a42a-6a46ced35bca
Record created2010-11-05
Record modified2016-05-09
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