Constituents of Chinese propolis and their antiproliferative activities

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DOIResolve DOI: http://doi.org/10.1021/np010486c
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TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
1520-6025
Volume65
Issue5
Pages673676; # of pages: 4
AbstractTwo new flavonoids, 3-O-[(S)-2-methylbutyroyl]pinobanksin (1) and 6-cinnamylchrysin (2), were isolated from the EtOAc-soluble fraction of the MeOH extract of Chinese propolis, along with 12 known compounds (3−14). The structures of the isolated compounds were elucidated on the basis of spectroscopic and chemical analyses. The isolated compounds were tested for their antiproliferative activity toward five different cancer cell lines. Benzyl caffeate (13) and phenethyl caffeate (14) showed potent antiproliferative activity toward tested cell lines with a selective activity toward colon 26-L5 carcinoma cell line (EC50 values:  13, 1.01; 14, 0.30 μM).
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LanguageEnglish
Peer reviewedYes
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NPARC number21274779
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Record identifier664325a7-2712-4e90-8a44-56ea806d5892
Record created2015-04-08
Record modified2016-05-09
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