The role of histones in avian erythropoiesis

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EditorSearch for: Pollak, J.K.; Search for: Lee, J. Wilson
TypeBook Chapter
Book titleThe Biochemistry of Gene Expression in Higher Organisms
Pages177190; # of pages: 14
AbstractThe maturation process in the nucleated avian erythrocyte has been shown to involve complete cessation of DNA synthesis and cell division (Cameron and Kastberg, 1969; Attardi et al., 1970), pronounced reduction in RNA and protein synthesis (Cameron and Kastberg, 1969; Attardi et al., 1970; Cameron and Prescott, 1963; Scherrer et al., 1966; Kabat and Attardi, 1967), marked nuclear condensation (Kernell et al., 1971; Brasch et al., 1971) increased haemoglobin content and decreased cell buoyancy (Kabat and Attardi, 1967; Mathias et al., 1969; Adams et al., 1971). Furthermore, the erythrocyte nucleus contains major proportions of a characteristic histone V or f2c (Neelin et al., 1964; Hnilica, 1964). Although the actual role in vivo of this highly basic histone is unknown, recent studies indicate that it may function both as a repressor of the genome (Seligy and Neelin, 1970) and as an agent supporting condensation of the chromatin in the mature erythrocyte (Brasch et al., 1972).
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AffiliationNational Research Council Canada
Peer reviewedNo
NPARC number21274597
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Record identifier66b610f4-cab0-414d-b104-1ede1d19ffd0
Record created2015-03-18
Record modified2016-05-09
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