Alternate synthesis to d-glycero-β-d-manno-heptose 1,7-biphosphate

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DOIResolve DOI: http://doi.org/10.1016/j.carres.2017.08.011
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TypeArticle
Journal titleCarbohydrate Research
ISSN0008-6215
Volume450
Pages3843
Subjectd-glycero-β-d-manno-heptose 1,7-biphosphate (HBP); Nuclear factor-kappa B (NF-κB); Pathogen-associated molecular pattern (PAMP); Wittig reaction; TRAF-interacting with forkhead-associated domain protein A (TIFA)
Abstractd-glycero-β-d-manno-heptose 1,7-biphosphate (HBP) is an enzymatic intermediate in the biosynthesis of the heptose component of lipopolysaccharide (LPS), and was recently revealed to be a pathogen-associated molecular pattern (PAMP) that allows detection of Gram-negative bacteria by the mammalian immune system. Cellular detection of HBP depends upon its stimulation of a cascade that leads to the phosphorylation and assembly of the TRAF-interacting with forkhead-associated domain protein A (TIFA), which activates the transcription factor NF-κB. In this note, an alternate chemical synthesis of HBP is described and its biological activity is established, providing pure material for further assessing and exploiting the biological activity of this compound.
Publication date
PublisherElsevier
LanguageEnglish
Peer reviewedYes
NPARC number23002594
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Record identifier6820abb9-4a39-44e6-b2eb-3508968d2d28
Record created2017-12-05
Record modified2017-12-05
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