An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in Alzheimer’s disease, mild cognitive impairment, and normal aging

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DOIResolve DOI: http://doi.org/10.1159/000319537
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TypeArticle
Journal titleDementia and Geriatric Cognitive Disorders
Volume30
Issue2
Pages121130; # of pages: 10
SubjectAging; Alzheimer’s disease; Brain lesions; Brain atrophy; Mild cognitive impairment
AbstractBackground: This study investigates how T1-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer’s disease (AD) and normal aging. Methods: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. Results: The T1- and T2-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. Conclusion: The T1-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number17673480
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Record identifier68962b02-02bc-4445-9886-99b8e867023d
Record created2011-04-03
Record modified2016-05-09
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