Metal-free, acid-catalyzed ortho -directed synthesis of anthranilic acid derivatives using carbodiimides

Download
  1. (PDF, 431 KB)
  2. Get@NRC: Metal-free, acid-catalyzed ortho -directed synthesis of anthranilic acid derivatives using carbodiimides (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1021/acs.orglett.5b01160
AuthorSearch for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleOrganic Letters
ISSN1523-7060
Volume17
Issue11
Pages27442747; # of pages: 4
AbstractOne-pot syntheses of fluorescent o-aminobenzoates, o-aminopyridine carboxylates, and a 2′-amino-[1,1′-biphenyl]-2-carboxylic acid are described. Carbodiimides are used as the source of the 2-amino function which inserts onto an aromatic ring using S<inf>N</inf>Ar reaction conditions. This method proceeds regiospecifically with a range of 2-fluoroaromatic acids or esters bearing further aryl fluorine, trifluoromethyl, and cyano substituents.
Publication date
PublisherACS Publications
LanguageEnglish
AffiliationNational Research Council Canada; Information and Communication Technologies
Peer reviewedYes
NPARC number21275769
Export citationExport as RIS
Report a correctionReport a correction
Record identifier68fd97c9-c27d-4c12-a5d4-a8514ca1d035
Record created2015-07-14
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)