Synthesis and Characterization of N2S3X-Fe Models of Iron-Containing Nitrile Hydratase

Download
  1. Get@NRC: Synthesis and Characterization of N2S3X-Fe Models of Iron-Containing Nitrile Hydratase (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1021/ic026239tS0020-1669(02)06239-0
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleInorganic Chemistry
ISSN00201669
Volume42
Issue14
Pages43824388; # of pages: 7
AbstractA series of iron complexes based on the pentadentate ligand 4,7-bis(2'-methyl-2'-mercaptopropyl)-1-thia-4,7-diazacyclononane), (bmmp-TASN)2-, have been synthesized and characterized as models of iron-containing nitrile hydratase (NHase). The chloro derivative [(bmmp-TASN)FeIIICl]?0.5EtOH (1) contains a labile chloride which facilitates synthesis of related complexes via substitution reactions. Complex 1 is high-spin, g = 4.28. Addition of NEt4CN with 1 in CH2Cl2 results in the cyanide ligated complex [(bmmp-TASN)FeIIICN]?0.5EtOH (2), which shows a single intense CN band at 2083 cm-1 in the IR region. Complex 2 is low-spin, g1 = 2.31, g2 = 2.16, and g3 = 1.96. Under basic conditions complex 1 affords a -oxo bridged dimeric Fe(III) complex [(bmmp-TASN)FeIII]2O (3), which shows an intense band at 799 cm-1. Complex 3 was recrystallized from CH2Cl2/hexane solution in the triclinic space group P, with a = 10.5486(15) ?, b = 13.0612(19) ?, c = 8.1852(12) ?, = 96.923(2), = 112.729(2), = 81.048(2), and Z = 1. Density functional theory (DFT) calculations of the previously communicated iron-nitrosyl complex [(bmmp-TASN)FeIII(NO)][BPh4] (4) (Inorg. Chem. 2002, 41, 1039-1041) reveal that the HOMO region is dominated by Fe-S bonding. Complexes 1-4 display irreversible or quasi-reversible reductions in the cyclic voltammograms. All of the iron complexes and the zinc derivative, (bmmp-TASN)Zn (5), display an irreversible oxidation. Complex 5 was crystallized in the monoclinic space group P21/n with a = 9.5759(6) ?, b = 20.9790(13) ?, c = 10.7113(7) ?, = 91.283(1), and Z = 4.
Publication date
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier10007817
NPARC number12328388
Export citationExport as RIS
Report a correctionReport a correction
Record identifier69ae304c-a3e6-4e4c-8fda-a84037152643
Record created2009-09-10
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)