Assessment of tissue oxygenation of periodontal inflammation in smokers using optical spectroscopy

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DOIResolve DOI: http://doi.org/10.1111/jcpe.12225
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TypeArticle
Journal titleJournal of Clinical Periodontology
ISSN0303-6979
Volume41
Issue4
Pages340347; # of pages: 8
AbstractBackground We have recently developed a periodontal diagnostic tool that was validated in non-smokers with periodontitis. Tobacco smoking is a recognized risk factor for periodontal diseases that can mask gingival bleeding and lead to a false negative diagnosis. Therefore, the purpose of current study is to further validate this instrument in smokers with periodontal diseases. Methods Using a portable optical near-infrared spectrometer, optical spectra were obtained, processed and evaluated from healthy (n = 108), gingivitis (n = 100), and periodontitis (n = 79) sites of 54 systemically healthy smokers. A modified Beer-Lambert unmixing model that incorporates a non-parametric scattering loss function was used to determine the relative contribution of deoxygenated haemoglobin (Hb) and oxygenated haemoglobin (HbO2) to the overall spectrum. The balance between tissue oxygen delivery and utilization in periodontal tissues was then assessed. Results Tissue oxygen saturation was significantly decreased in the gingivitis (p = 0.016) and periodontitis (p = 0.007) sites, compared to the healthy sites. There was a trend towards increased concentration of Hb and decreased concentration of HbO2 from healthy to diseased sites, without statistical significance (p > 0.05). Conclusions Optical spectroscopy can determine tissue oxygenation profiles of healthy and diseased sites in smokers. The spectral profile of periodontal sites in smokers generally resembles those from non-smoking patients. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); Medical Devices (MD-DM)
Peer reviewedYes
NPARC number21272117
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Record identifier6a431ab4-0cbb-41dc-a8b3-94c8e5a6850a
Record created2014-07-23
Record modified2016-05-09
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