Armand-frappier outstanding student award — The emerging role of 25-hydroxycholesterol in innate immunity

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DOIResolve DOI: http://doi.org/10.1139/cjm-2015-0292
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TypeArticle
Journal titleCanadian Journal of Microbiology
ISSN0008-4166
Volume61
Issue8
Pages521530; # of pages: 10
Subject25 hydroxycholesterol; cholesterol-25-hydroxylase; metabolism; virus; immunity
AbstractThe metabolic interplay between hosts and viruses plays a crucial role in determining the outcome of viral infection. Viruses reorchestrate the host’s primary metabolic gene networks, including genes associated with mevalonate and isoprenoid synthesis, to acquire the necessary energy and structural components for their viral life cycles. Recent work has demonstrated that the interferon-mediated antiviral response suppresses the sterol pathway through production of a signalling molecule, 25-hydroxycholesterol (25HC). This oxysterol has been shown to exert multiple effects, both through incorporation into host cellular membranes as well as through transcriptional control. Herein, we summarize our current understanding of the multifunctional roles of 25HC in the mammalian innate antiviral response.
Publication date
LanguageEnglish
AffiliationMedical Devices; National Research Council Canada
Peer reviewedYes
NPARC number21277025
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Record identifier6ba5f2ab-e963-499a-9ca2-e7c6a7f2d225
Record created2015-11-10
Record modified2016-05-09
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