Surface plasmon resonance biomolecular recognition nanosystem : influence of the interfacial electrical potential

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DOIResolve DOI: http://doi.org/10.1166/jnn.2014.9354
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TypeArticle
Journal titleJournal of Nanoscience and Nanotechnology
ISSN1533-4880
Volume14
Issue9
Pages65596564; # of pages: 6
SubjectSurface plasmon resonance; Biomolecular adsorption; Biomolecular recognition; Electrical double layers; Electrical potential; Biosensors
AbstractIt is shown that the response of a surface plasmon resonance nanosystem designed according to Kretschmann geometry on the application of an external electric potential to the gold-electrolyte interface is well described by the proposed mathematical model, which takes into account the geometric surface imperfection and dependence of optical constants of the surface layer of gold film and capacitance of the electrical double layer on applied voltage. This model allows the appropriate correction for results of electrochemical surface plasmon resonance measurements. The dependence of a value of biomolecules adsorption in a surface plasmon resonance nanosystem on applied electric potential is shown for the first time. It is found that a shift of surface plasmon resonance angular position (ΔθSPR) and a change of capacitance of electrical double layer on the surface of gold (Δ Cdl) for the adsorption of proteins under applied voltage are related to the nonlinear dependence ΔθSPR= (a+b ΔCdl)-1. This phenomenon can be exploited in biochemical analysis to monitor the interaction of biomolecules, enhance response of biosensors, block unwanted adsorption, etc.
Publication date
LanguageEnglish
AffiliationEnergy, Mining and Environment; National Research Council Canada
Peer reviewedYes
NPARC number21272685
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Record identifier6cc5dab3-714e-4163-a189-5fa922fa6e19
Record created2014-12-03
Record modified2016-05-09
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