Lipid peroxidation in regenerating rat liver

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DOIResolve DOI: http://doi.org/10.1016/0014-5793(86)81109-7
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TypeArticle
Journal titleFEBS Letters
ISSN0014-5793
Volume209
Issue2
Pages191196; # of pages: 6
Subjectlipid peroxide; thymidine kinase; animal cell; dna synthesis; liver; liver regeneration; microsome; nonhuman; priority journal; rat; Animals; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Kinetics; Lipid Peroxides; Liver; Liver Regeneration; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Rats; Rats, Inbred Strains; Thymidine Kinase; Vitamin E; Animalia
AbstractRats entrained to a strictly regulated lighting and feeding schedule have been subjected to partial hepatectomy or a sham operation. In the partially hepatectomised animals the period of liver regeneration is characterised by regular bursts of thymidine kinase activity. Liver microsomes from rats, at times corresponding to maximum thymidine kinase activity, have much reduced rates of lipid peroxidation compared to control preparations: this is due in part to increased levels of lipid-soluble antioxidant at times of maximal DNA synthesis. This temporal relationship between thymidine kinase and lipid peroxidation is consistent with the view that lipid peroxidation is decreased prior to cell division. © 1986.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276534
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Record identifier6d8c72d4-210a-4690-bbe9-bd5b75f7064b
Record created2015-10-13
Record modified2016-05-09
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