A comparison of rat SPECT images obtained using ⁹⁹mTc derived from ⁹⁹Mo produced by an electron accelerator with that from a reactor

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DOIResolve DOI: http://doi.org/10.1088/0031-9155/58/9/2737
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TypeArticle
Journal titlePhysics in Medicine and Biology
ISSN0031-9155
1361-6560
Volume58
Issue9
Pages27372750; # of pages: 14
AbstractRecent shortages of molybdenum-99 (⁹⁹Mo) have led to an examination of alternate production methods that could contribute to a more robust supply. An electron accelerator and the photoneutron reaction were used to produce ⁹⁹Mo from which technetium-99m (⁹⁹mTc) is extracted. SPECT images of rat anatomy obtained using the accelerator-produced ⁹⁹mTc with those obtained using ⁹⁹mTc from a commercial generator were compared. Disks of 100Mo were irradiated with x-rays produced by a 35 MeV electron beam to generate about 1110 MBq (30 mCi) of ⁹⁹Mo per disk. After target dissolution, a NorthStar ARSII unit was used to separate the ⁹⁹mTc, which was subsequently used to tag pharmaceuticals suitable for cardiac and bone imaging. SPECT images were acquired for three rats and compared to images for the same three rats obtained using ⁹⁹mTc from a standard reactor ⁹⁹Mo generator. The efficiency of ⁹⁹Mo–⁹⁹mTc separation was typically greater than 90%. This study demonstrated the delivery of ⁹⁹mTc from the end of beam to the end user of approximately 30 h. Images obtained using the heart and bone scanning agents using reactor and linac-produced ⁹⁹mTc were comparable. High-power electron accelerators are an attractive option for producing ⁹⁹Mo on a national scale.
Publication date
LanguageEnglish
AffiliationMeasurement Science and Standards; National Research Council Canada
Peer reviewedYes
NPARC number21268452
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Record identifier6db87c20-830f-40f8-922b-4e463ead114f
Record created2013-07-23
Record modified2016-05-09
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