Lipid bilayer – DNA interaction mediated by divalent metal cations : SANS and SAXD study

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DOIResolve DOI: http://doi.org/10.1088/1742-6596/351/1/012011
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TypeArticle
Journal titleJournal of Physics : Conference Series
Volume351
Issue1
Article number012011
Pages19; # of pages: 9
AbstractThe structure of aggregates formed due to DNA interaction with dipalmitoylphosphatidylcholine (DPPC) in presence of Ca2+ and Zn2+ is examined using small-angle synchrotron X-ray diffraction (SAXD) and small-angle neutron scattering (SANS). SAXD detected two structures: LC - condensed lamellar phase and LX - lamellar phase with DNA strands intercalated between the adjacent lipid bilayers, without regular packing at low cation concentration (~1 mM). The high concentration of Zn2+ induces a macroscopic phase separation in mixtures. The SANS curves of DPPC+ions2+ vesicles evaluated using the strip function model have shown different modes of cations binding to the DPPC bilayers.
Publication date
PublisherIOP Science
LanguageEnglish
AffiliationNRC Canadian Neutron Beam Centre; National Research Council Canada
Peer reviewedYes
NPARC number21268039
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Record identifier6ed13fbc-d0a4-4610-be4c-ca196d807514
Record created2013-04-04
Record modified2016-05-09
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