Effect of orally administered alpha-tocopheryl acetate on human myocardial alpha-tocopherol levels

  1. Get@NRC: Effect of orally administered alpha-tocopheryl acetate on human myocardial alpha-tocopherol levels (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1007/BF00054753
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Journal titleCardiovascular Drugs and Therapy
Issue2 Supplement
Pages309312; # of pages: 4
Subjectalpha tocopherol; deuterium; angina pectoris; bypass surgery; clinical article; conference paper; heart left ventricle; human; isotope labeling; oral drug administration; priority journal; reperfusion; Administration, Oral; Coronary Artery Bypass; Human; Myocardial Reperfusion; Myocardium; Preoperative Care; Support, Non-U.S. Gov't; Vitamin E
AbstractFree radical injury may contribute to the delayed postoperative recovery of myocardial metabolism and ventricular function after elective coronary artery revascularization. This clinical study was designed to evaluate, in stable angina patients having aortocoronary bypass surgery [1], whether orally administered alpha-tocopheryl acetate was effective in increasing myocardial alpha-tocopherol levels and [2] the effect of cardioplegic arrest followed by reperfusion on the myocardial alpha-tocopherol levels. Twenty-four patients with stable angina pectoris for elective revascularization received preopertatively the natural stereoisomer of alpha-tocopheryl acetate labelled with deuterium (D3) and six patients were used as controls. Since four patients who received 300 mg of D3-alpha-tocopheryl acetate preoperatively for 1 and 2 days did not have significant increases in their myocardial total or D3-tocopherol levels, the remaining 20 patients received 100 mg (n=6), 300 mg (n=8), or 900 mg (n=6) of D3-alpha-tocopheryl acetate for 14 consecutive preoperative days. The left ventricular deuterated and non-deuterated alpha-tocopherol levels were measured by gas chromatography/mass spectrometry. Although there was a decrease (p < 0.05) in myocardial alpha-tocopherol levels with the onset of reperfusion (cross-clamp removal), the myocardial tocopherol levels were not statistically different from preoperative levels by 20 minutes of reperfusion. At least 300 mg of alpha-tocopherol must be taken orally for 14 consecutive days to double the myocardial alpha-tocopherol levels. © 1991 Kluwer Academic Publishers.
Publication date
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276795
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Record identifier6f2e33cf-bf3d-4bfd-8925-ac439d9caeba
Record created2015-10-13
Record modified2016-05-09
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