Neurovascular protection conferred by 2-BFI treatment during rat cerebral ischemia

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DOIResolve DOI: http://doi.org/10.1016/j.bbrc.2012.06.152
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TypeArticle
Journal titleBiochemical and Biophysical Research Communications
ISSN0006-291X
Volume424
Issue3
Pages544548; # of pages: 5
SubjectFocal cerebral ischemia; 2-(2-Benzofu-ranyl)-2-imidazoline; 2-BFI; Middle cerebral artery occlusion model; FITC-dextran
AbstractStroke is caused by vascular dysfunction and currently there are no effective therapeutics to stroke induced brain damage. In contrast to an intense emphasis on neuroprotection, relatively few studies have addressed means of vascular protection in cerebral ischemia. Here we discovered that the ligand to immidazolin receptor, 2-BFI, not only provided potent neuroprotection during middle cerebral artery occlusion in rat, which confirmed our previous reports, but also protected the integrity of the cerebral vasculature. Treatment with 2-BFI twice daily after the occlusion of the middle cerebral artery for 14 d significantly improved the neurological deficits, reduced brain infarction, and importantly, protected the cerebral vasculature as evidenced by the increased expression of an endothelial marker, von Willebrand factor, and better preservation of the cerebral vasculature, as viewed under a confocal microscope on rat brain perfused with FITC-labeled dextran. These results indicated that 2-BFI contributes to protection of neurovasculature. Understanding the molecular mechanisms could eventually lead to development of more effective therapies for stroke.
Publication date
LanguageEnglish
AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
IdentifierS0006291X12012636
NPARC number21268674
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Record identifier6f7df61f-e5aa-400f-86f1-b3cd209647da
Record created2013-11-07
Record modified2016-05-09
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