The structure of the O-antigen of Cronobacter sakazakii HPB 2855 isolate involved in a neonatal infection

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DOIResolve DOI: http://doi.org/10.1016/j.carres.2010.06.020
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TypeArticle
Journal titleCarbohydrate Research
Volume345
Issue13
Pages19321937; # of pages: 6
SubjectCronobacter sakazakii; Lipopolysaccharide; Polysaccharide; O-Antigen; NMR spectroscopy
AbstractStrains of Cronobacter sakazakii (previously known as Enterobacter sakazakii) are medically recognized important Gram-negative bacterial pathogens that cause enterocolitis, septicemia, and meningitis, with a high mortality rate in neonates. The structure of their O-antigens, that form part of their somatic lipopolysaccharide (LPS) components, is of interest for their chemical and serological identification and their relationship to virulence. The O-polysaccharide (O-PS) of C. sakazakii HPB 2855 (SK 81), a strain isolated from an infant at the Hospital for Sick Children in Toronto in 1981, was shown to be a polymer of a partially O-acetylated-repeating hexasaccharide unit composed of D-glucose, D-galacturonic acid, 2-acetamido- 2-deoxy-D-galactose, and L-rhamnose (1:1:1:3). From composition and methylation analysis, and the application of 1D and 2D 1H and 13C NMR spectroscopy, the O-PS was determined to be a polymer of a repeating oligosaccharide unit having the structure
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National ResearchCouncil Canada
Peer reviewedYes
NPARC number17652996
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Record identifier6f8e8ba6-ddb5-4ff7-88c2-3d97160cc142
Record created2011-04-01
Record modified2016-05-09
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