Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events

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DOIResolve DOI: http://doi.org/10.1016/j.jnutbio.2005.05.014
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TypeArticle
Journal titleJournal of Nutritional Biochemistry
Volume17
Issue2
Pages117125; # of pages: 9
Subjectflavonoids; MMP; PKC; MAP kinase; blueberry; cells
AbstractRegulation of the matrix metalloproteinases (MMPs) is crucial to regulate extracellular matrix (ECM) proteolysis which is important in metastasis. This study investigated the mechanism(s) by which three flavonoid-enriched fractions from lowbush blueberry (Vaccinium angustifolium) down-regulate MMP activity in DU145 human prostate cancer cells. Metalloproteinase activity was evaluated from cells exposed to “crude,” anthocyanin-enriched (AN) and proanthocyanidin-enriched (PAC) fractions. Differential down-regulation of MMPs was observed. The activity of the endogenous tissue inhibitors of metalloproteinases (TIMPs) from these cells was also evaluated. Increases in TIMP-1 and TIMP-2 activity were observed in response to these fractions. The possible involvement of protein kinase C (PKC) and mitogen-activated protein (MAP) kinase pathways in the flavonoid-mediated decreases in MMP activity was observed. These findings indicate that blueberry flavonoids may use multiple mechanisms in down-regulating MMP activity in these cells.
Publication date
PublisherElsevier
Copyright noticeCopyright 2006 Elsevier Inc. All rights reserved
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada; Aquatic and Crop Resource Development
Peer reviewedYes
NRC number1564
NPARC number3538548
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Record identifier6fcc3d5a-19bf-4ff8-88ad-8465e9e5551b
Record created2009-03-01
Record modified2016-05-09
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