A Small-Molecule Probe for Hepatitis C Virus Replication that Blocks Protein Folding

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DOIResolve DOI: http://doi.org/10.1016/j.chembiol.2006.08.010
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TypeArticle
Journal titleChemistry & Biology
Volume13
Issue10
Pages10511060; # of pages: 10
SubjectCHEMBIO; MICROBIO
AbstractSummary The hepatitis C virus (HCV) is a growing global health problem. Small molecules that interfere with host-viral interactions can serve as powerful tools for elucidating the molecular mechanisms of pathogenesis and defining new strategies for therapeutic development. Using?a cell-based screen involving subgenomic HCV replicons, we identified the ability of 18 different abscisic acid (ABA)?analogs, originally developed as plant growth regulators, to inhibit HCV replication. Three of these were further studied. One compound, here named origamicin, showed antiviral activity through the inhibition of host proteins involved in protein folding. Origamicin could therefore be an important tool for studying the maturation of both host and viral proteins. Herein we demonstrate an application for molecular scaffolds based on ABA for mammalian cell targets involved in protein folding.
Publication date
AffiliationNational Research Council Canada; NRC Genomics and Health Initiative; NRC Plant Biotechnology Institute
Peer reviewedNo
NPARC number12338326
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Record identifier70e73391-a889-49d7-929b-46e5c7ffa8de
Record created2009-09-10
Record modified2016-05-09
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