Lymphotoxin-alpha plays only a minor role in host resistance to respiratory infection with virulent type A Francisella tularensis in mice: Mediators.Inflamm.

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TypeArticle
Journal titleMediators.Inflamm.
Volume2008
Pages239740
SubjectAerosols; analysis; Animals; Bacteria; Bronchoalveolar Lavage Fluid; Canada; Cytokines; cytology; FLUID; Francisella tularensis; genetics; immunology; INFECTION; Lung; Lymphotoxin-alpha; Mice; Mice,Inbred C57BL; Mice,Knockout; Microbiology; mortality; pathogenicity; prevention & control; Role; Spleen; STRAIN; STRAINS; Survival Rate; Tularemia
AbstractThis study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice deficient in LTalpha (LTalpha-/-) consistently harbored approximately 10-fold fewer bacteria in their spleens at day 2 and 10-fold more bacteria in their lungs at day 4 than LTalpha+/+ mice. However, the mortality and median time to death were indistinguishable between the two mouse strains. In addition, the inflammatory responses to the infection, as reflected by the cytokine levels and leukocyte influx in the bronchoalveolar lavage fluid and histopathological analysis, were generally similar between LTalpha-/- and LTalpha+/+ mice. These data suggest that although LTalpha does not contribute significantly to the resistance and host responses of mice to airborne type A F. tularensis infection, it does play a subtle role in the multiplication/dissemination of F. tularensis
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberZHANG2008
NPARC number9367682
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Record identifier72561708-f3de-434b-a5f6-bbdeba96e662
Record created2009-07-10
Record modified2016-05-09
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