Maternal plasma levels of follistatin-related gene protein in the first trimester of pregnancies with Down syndrome

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DOIResolve DOI: http://doi.org/10.1002/pd.2441
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TypeArticle
Journal titlePrenatal Diagnosis
Volume30
Issue3
Pages224228; # of pages: 5
Subjectfollistatin-related proteins; pregnancy; first trimester; Down syndrome; aneuploidy
AbstractObjective: To determine maternal plasma levels of follistatin-related gene protein (FLRG) in the first trimester of pregnancy and assess its potential role as a marker for prenatal screening of Down syndrome. Methods: Maternal plasma levels of FLRG were determined in 100 pregnant women with normal fetuses in their first trimester of pregnancy (i.e. 11th to 15th weeks). These results were compared with 20 cases with Down syndrome fetuses, taking into consideration clinical and demographic variables, such as maternal age, maternal weight, gestational age, smoking status and ethnicity. Results:Maternal plasma median of FLRG in the normal population was 1.41 ng/mL with 95% confidence interval (CI) of 1.37–1.70 and interquartile range (IQR) of 0.88, during the 11th to 15th weeks of pregnancy. Maternal age and weight were the only variables significantly related to FLRG levels (p = 0.030 and 0.020, respectively). Only maternal and gestational ages were related to Down syndrome (p = 0.039 and 0.006, respectively). Maternal plasma levels of FLRG were not significantly different in the presence of Down syndrome fetuses compared to normal population (p = 0.63). Conclusion: FLRG can be successfully detected in maternal plasma in the first trimester of pregnancy. However, its levels are not significantly altered in the presence of Down syndrome fetuses.
Publication date
LanguageEnglish
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedYes
NRC number50679
NPARC number16541828
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Record identifier731c15d5-e23e-4d75-ab85-68e0baa7a228
Record created2011-03-31
Record modified2016-05-09
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