Towards low cost disposable high throughput screening devices

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DOIResolve DOI: http://doi.org/10.1557/PROC-0897-J03-03
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TypeArticle
Proceedings title2005 MRS Fall Meeting, Symposium J, Biomemetic Polymers and Gels
Series titleMRS Proceedings; no. 897
Conference2005 MRS Fall Meeting and Exhibit, November 27-December 2, 2005, Boston, Massachusetts USA
ISSN1946-4274
Article number0897-J03-03
Subjectbiomedical; surface chemistry; polymer
AbstractMicroarrays have become one of the most convenient tools for high throughput screening, supporting major advances in genomics and proteomics. Other important applications can be found in medical diagnostics, detection of biothreats, drug discovery, etc. Integration of microarrays with microfluidic devices can be highly advantageous in terms of portability, shorter analysis time and lower consumption of expensive biological analytes. Since fabrication of microfluidic devices using traditional materials such as glass is rather expensive, there is a high interest in employing polymeric materials as a low cost alternative that is suitable for mass production. A number of commercially available plastic materials were reviewed for this purpose and poly(methylmethacrylate) and Zeonor™ 1060R were identified as promising candidates, for which methods for surface modification and covalent immobilization of DNA oligonucleotide were developed. In addition, we present proof-of-concept plastic-based microarrays with and without integration with microfluidics.
Publication date
PublisherMaterials Research Society
LanguageEnglish
AffiliationNRC Industrial Materials Institute; NRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedYes
NPARC number21277293
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Record identifier7825b9bb-2fcf-470c-9abd-34f7aec20493
Record created2016-02-10
Record modified2016-05-09
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