The Otto Aufranc Award : demineralized bone matrix around porous implants promotes rapid gap healing and bone ingrowth

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DOIResolve DOI: http://doi.org/10.1007/s11999-011-2011-y
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TypeArticle
Journal titleClinical Orthopaedics and Related Research
ISSN0009-921X
1528-1132
Volume470
Issue2
Pages357365; # of pages: 9
AbstractBackground Noncemented revision arthroplasty is often complicated by the presence of bone implant gaps that reduce initial stability and biologic fixation. Demineralized bone matrix has osteoinductive properties and therefore the potential to enhance gap healing and porous implant fixation. Questions/purposes We determined at what times and to what extent demineralized bone matrix promotes gap healing and bone ingrowth around a porous implant. Methods We inserted porous titanium implants into the proximal metaphyses of canine femora and humeri, with an initial 3-mm gap between host cancellous bone and implants. We left the gaps empty (control; n = 12) or filled them with either demineralized bone matrix (n = 6) or devitalized demineralized bone matrix (negative control; n = 6) and left them in situ for 4 or 12 weeks. We quantified volume healing of the gap with new bone using three-dimensional micro-CT scanning and quantified apposition and ingrowth using backscattered scanning electron microscopy. Results The density of bone inside gaps filled with demineralized bone matrix reached 64% and 93% of surrounding bone density by 4 and 12 weeks, respectively. Compared with empty controls and negative controls at 4 and 12 weeks, gap healing using demineralized bone matrix was two to three times greater and bone ingrowth and apposition were up to 15 times greater. Conclusions Demineralized bone matrix promotes rapid bone ingrowth and gap healing around porous implants. Clinical Relevance Demineralized bone matrix has potential for enhancing implant fixation in revision arthroplasty.
Publication date
LanguageEnglish
AffiliationNRC Industrial Materials Institute; National Research Council Canada
Peer reviewedYes
Identifier2011
NPARC number21268435
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Record identifier78359400-81cf-4f0e-8370-814331c19605
Record created2013-07-15
Record modified2016-05-09
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